Induction of long-term protective immune responses by influenza H5N1 virus-like particles.
Recurrent outbreaks of highly pathogenic H5N1 avian influenza virus pose a threat of STICKERS eventually causing a pandemic.Early vaccination of the population would be the single most effective measure for the control of an emerging influenza pandemic.Influenza virus-like particles (VLPs) produced in insect cell-culture substrates do not depend on